Activated Protein C (APC)
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Activated protein C (with protein S as a cofactor) degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired. The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII concentrations.
Human activated protein C is a serine protease which is derived from the two chain vitamin K dependent zymogen.It is used to inhibit blood coagulation through the selective inactivation of the cofactors Va and VLLA.It is indicated for use in the treatment and reduction of mortality in cases of severe sepsis, though the mechanism by which it achieves this reduction is not clearly defined or understood.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA738Hu01 Recombinant Activated Protein C (APC) In Stock
- Polyclonal antibody PAA738Hu01 Polyclonal Antibody to Activated Protein C (APC) In Stock
- Sandwich ELISA SEA738Hu ELISA Kit for Activated Protein C (APC) In Stock
- High-sensitive ELISA HEA738Hu High Sensitive ELISA Kit for Activated Protein C (APC) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPA738Mu01 Recombinant Activated Protein C (APC) In Stock
- Polyclonal antibody PAA738Mu01 Polyclonal Antibody to Activated Protein C (APC) In Stock
- Sandwich ELISA SEA738Mu ELISA Kit for Activated Protein C (APC) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPA738Ra01 Recombinant Activated Protein C (APC) In Stock
- Polyclonal antibody PAA738Ra01 Polyclonal Antibody to Activated Protein C (APC) In Stock
- Sandwich ELISA SEA738Ra ELISA Kit for Activated Protein C (APC) In Stock