Activating Transcription Factor 1 (ATF1)
EWS-ATF1; FUS/ATF-1; TREB36; Cyclic AMP-Dependent Transcription Factor
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This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP(basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.
Activating Transcription Factor 1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB346Hu01 Recombinant Activating Transcription Factor 1 (ATF1) In Stock
- Polyclonal antibody PAB346Hu01 Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) In Stock
- Sandwich ELISA SEB346Hu ELISA Kit for Activating Transcription Factor 1 (ATF1) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPB346Mu01 Recombinant Activating Transcription Factor 1 (ATF1) In Stock
- Polyclonal antibody PAB346Mu01 Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) In Stock
- Customized Service n/a CLIA Kit for Activating Transcription Factor 1 (ATF1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Activating Transcription Factor 1 (ATF1) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPB346Ra01 Recombinant Activating Transcription Factor 1 (ATF1) In Stock
- Polyclonal antibody PAB346Ra01 Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) In Stock
- Customized Service n/a CLIA Kit for Activating Transcription Factor 1 (ATF1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Activating Transcription Factor 1 (ATF1) ELISA Kit Customized Service Offer