Acylphosphatase 1, Erythrocyte (ACYP1)

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization.

Acylphosphatase 1 is the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.All the clones were incomplete at the 5-prime end, but Northern blot analysis using cDNA as a probe showed the presence of an unusually long 5-prime untranslated region in the mRNA. Southern blot analysis of DNA from different individuals revealed a simple hybridization pattern.