Adenosine Monophosphate Deaminase 2 (AMPD2)

Adenosine monophosphate deaminase-2 (EC 3.5.4.6) catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.

The deduced 760-amino acid polypeptide has a predicted molecular mass of 88.1 kD and shares significant homology in the C-terminal region with AMPD1. AMPD2 encodes isoform L (liver).AMPD2 is the predominant gene expressed in nonmuscle tissues and smooth muscle of the adult rat and is also the predominant gene expressed in embryonic muscle and undifferentiated myoblasts. Both genes are expressed in cardiac muscle of the adult rat. The peptides encoded by these 2 genes have distinct immunologic properties. Human isoform L corresponds to rat isoform B (liver and kidney).