Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g)

The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li⁺-ions, protons and especially Na⁺-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel.

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. Amiloride Sensitive Sodium Channel Subunit Gammaisthe gamma subunit, and mutations in this gene have been associated with Liddle syndrome..