Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1)
NAE1; HPP1; Ula-1; NEDD8-Activating Enzyme E1 Regulatory Subunit 1; Amyloid protein-binding protein 1; Proto-oncogene protein 1
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NEDD8-activating enzyme E1 regulatory subunit binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
The APPBP1 protein is 39% identical to the protein encoded by the Arabidopsis auxin resistance gene AXR1; both proteins are relatives of ubiquitin-activating enzyme-1 (UBE1).
Organism species: Homo sapiens (Human)
- Recombinant protein RPC219Hu01 Recombinant Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) In Stock
- Polyclonal antibody PAC219Hu01 Polyclonal Antibody to Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) In Stock
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a CLIA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1) ELISA Kit Customized Service Offer