Androgen Induced Proliferation Inhibitor (APRIN)
PDS5B; AS3; PDS5,Regulator Of Cohesion Maintenance B; Sister chromatid cohesion protein PDS5B; Androgen-induced prostate proliferative shutoff-associated protein AS3
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In the prostate of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G0/G1 phase. The expression pattern of one of these sequences, designated AS3, strongly correlated with the expression of the androgen-induced proliferative shutoff both temporally and dosewise. The AS3 gene is upregulated during androgen-induced proliferative shutoff and induces cell proliferation arrest when expressed in a retrovirus transduced model. The deduced 1,391-amino acid AS3 protein has putative transactivating features, protein-protein interaction motifs (coiled coil and leucine zipper), and DNA-binding domains, suggesting that AS3 is a transcription factor. AS3 also has a protein-kinase motif, suggesting that it may act by phosphorylating a target protein.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Androgen Induced Proliferation Inhibitor (APRIN) Recombinant Protein Customized Service Offer
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- Customized Service n/a Polyclonal Antibody to Androgen Induced Proliferation Inhibitor (APRIN) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Androgen Induced Proliferation Inhibitor (APRIN) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Androgen Induced Proliferation Inhibitor (APRIN) ELISA Kit Customized Service Offer