Angiogenin 3 (ANG3)

EF-5; Angl; Angiogenin-Related Protein 2

Angiogenin 3 (ANG3)
Mouse angiogenin-3 has been identified by virtue of its transcriptional activation in NIH 3T3 fibroblasts coincident with transformation by the chimeric leukemia oncogene, E2a-Pbx1. The protein has been identified independently as EF-5, a gene expressed in NIH 3T3 fibroblast following transformation with the E2a-Pbx1 oncoprotein. Other names for angiogenin-3 in databanks are Angrp2 and Angl, and Rnase5c .
Angiogenin-3 is a ribonuclease. Its activity and specificity towards tRNA and dinucleotide substrates differs from those of mouse angiogenin or of mouse angiogenin-related protein, a non-angiogenic factor. Mouse angiogenin-3 induces angiogenesis in both the Chicken chorioallantoic membrane assay and the rat cremaster muscle.

Organism species: Mus musculus (Mouse)