Annexin A10 (ANXA10)

ANXA10 is a member of the annexin family of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and homologous C-terminal domains containing the calcium-dependent phospholipid-binding sites. The deduced human 324-amino acid protein shares approximately 89% sequence identity with the mouse protein. ANXA10 was found to be the least represented annexin in the EST database, and its expression was detected only in nondifferentiated tissues. Other distinctive features of ANXA10 included a codon deletion in conserved repeat 3, and an unusual ablation of the type II calcium-binding sites in tetrad core repeats 1, 3, and 4. ANXA10 expression might indicate cellular proliferation and ANXA10 might be a potential therapeutic target for the development of new treatments for OSCCs.