Annexin A11 (ANXA11)

Annexin A11 isa 56-kD antigen recognized by sera from patients with various autoimmune diseases. Exon 1 is untranslated, and intron 1 spans about 20 kb. The human ANXA11 gene has the same general structure as the mouse gene; however, EST database analysis indicated that human ANXA11 transcripts also use variably spliced exons 1b and 1c, which can lengthen the 5-prime UTR. The intronic sequences of the mouse and human ANXA11 genes contain several types of repetitive elements, including retroviral long terminal repeats. The mouse promoter region contains a remnant LINE-1 insertion not found in the human gene. The 5-prime flanking region of the ANXA11 gene contains a CpG island and MYOD, SP1, and glucocorticoid response elements, but no proximal TATA or CAAT boxes.