Ataxia Telangiectasia Group D Associated Protein (ATDC)

TRIM29 belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation.

ATDC, a candidate gene for ataxia-telangiectasia (AT) that maps to the region of chromosome 11q23 containing the AT locus. RNA blot analysis detected ATDC transcripts of 1.8, 2.6, 3.0, 4.7, and 5.7 kb that were variably expressed among different cell lines. The 3.0-kb transcript, which corresponds to the cDNA isolated from HeLa cells, was the most abundant transcript in HeLa cells. Southern blot analysis indicated that ATDC is a single-copy gene in the human genome.