Atlastin 2 (ATL2)
ARL6IP2; Aip-2; ADP-Ribosylation Factor-Like 6 Interacting Protein 2; Atlastin GTPase 2; ARL-6-interacting protein 2
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By positional cloning, Zhao et al. (2001) demonstrated that a form of autosomal dominant hereditary spastic paraplegia with early onset (SPG3A), before the age of 10 years and usually before the age of 5, is caused by mutation in a GTPase gene. The gene was found to have no homology to genes that cause other forms of hereditary spastic paraplegia. It does show significant homology to guanylate binding protein-1 (GBP1; ), a member of the dynamin family of large GTPases.
By searching databases for sequences similar to atlastin-1 (SPG3A), Zhu et al. (2003) identified ARL6IP2, which they called atlastin-2. The deduced 579-amino acid protein contains GTP-binding motifs in its N-terminal half and 2 transmembrane domains in its C-terminal half.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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