Autoimmune Regulator (AIRE)
AIRE1; APECED; APS1; APSI; PGA1; Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy
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The Autoimmune Regulator is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self. It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis. AIRE is expressed primarily in the thymus.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC322Hu01 Recombinant Autoimmune Regulator (AIRE) In Stock
- Polyclonal antibody PAC322Hu01 Polyclonal Antibody to Autoimmune Regulator (AIRE) In Stock
- Monoclonal antibody MAC322Hu22 Monoclonal Antibody to Autoimmune Regulator (AIRE) In Stock
- Sandwich ELISA SEC322Hu ELISA Kit for Autoimmune Regulator (AIRE) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPC322Mu01 Recombinant Autoimmune Regulator (AIRE) In Stock
- Recombinant protein RPC322Mu02 Recombinant Autoimmune Regulator (AIRE) In Stock
- Polyclonal antibody PAC322Mu01 Polyclonal Antibody to Autoimmune Regulator (AIRE) In Stock
- Polyclonal antibody PAC322Mu02 Polyclonal Antibody to Autoimmune Regulator (AIRE) In Stock
- Sandwich ELISA SEC322Mu ELISA Kit for Autoimmune Regulator (AIRE) In Stock
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Autoimmune Regulator (AIRE) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Autoimmune Regulator (AIRE) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Autoimmune Regulator (AIRE) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Autoimmune Regulator (AIRE) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Autoimmune Regulator (AIRE) ELISA Kit Customized Service Offer