Bcl2 Like Protein 12 (BCL2L12)

BCL2L12 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

The deduced 334-amino acid protein has a calculated molecular mass of 36.8 kD. It contains several PxxP motifs, a C-terminal BH2 domain, and multiple sites for O-glycosylation, phosphorylation, and N-myristoylation.BCL2L12 expression was upregulated in 53 of 55 human primary glioblastomas relative to surrounding normal brain tissue.