BMX Non Receptor Tyrosine Kinase (BMX)

BMX encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.BMX is transcribed in bone marrow as well as endothelial cells, and by Western blot analysis they detected an 80-kD protein corresponding to BMX in human endothelial cells. A similar size protein was identified in COS cells transfected with a BMX expression vector.