Benzodiazapine Receptor Associated Protein 1 (BZRAP1)

BZRAP1 has a calculated molecular mass of 200 kD and contains several domains involved in protein-protein interaction: 3 proline-rich domains, 3 leucine-zipper motifs, and an Src homology region-3-like domain. It has 2 potential N-glycosylation sites, 2 amidation site, 3 glycosaminoglycan attachment sites, and numerous putative phosphorylation sites. PRAX1 migrated as a 220- to 250-kD protein. Among fetal tissues, highest expression was in brain, followed by heart, kidney, and thymus. In brain, highest expression was in temporal lobe and putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital lobe, and frontal lobe. A similar expression pattern was found in mouse and rat tissues. PRAX1 expression was also observed in several human cell lines, and it was higher in cancer cell lines compared with normal tissues.