Bone Marrow-Derived Macrophage Cells (BMDM)

Bone Marrow-Derived Macrophage Cells (BMDMs) are macrophages generated in vitro from bone marrow hematopoietic stem cells (HSCs). They are widely used in immunology and biomedical research due to their plasticity and ability to model tissue-resident macrophage functions. BMDMs originate from myeloid progenitors, differentiating into monocytes and then macrophages under cytokine stimulation (e.g., M-CSF). They exhibit key macrophage characteristics, including phagocytosis, antigen presentation, and immune regulation. BMDMs can polarize into M1 (pro-inflammatory) or M2 (anti-inflammatory) subtypes, depending on environmental cues, making them valuable for studying immune responses, cancer, infectious diseases, and tissue repair. BMDMs are instrumental in drug screening, tissue engineering, and understanding macrophage biology.