Bone Morphogenetic Protein 3 (BMP3)

Bone morphogenetic protein 3 is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts. Expressed in adult and fetal cartilage.