Bradykinin Receptor B2 (BDKRB2)
BDKR-B2; B2R; BK2; BKR2; BRB2
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Bradykinin receptor B2 (B2) is a g-protein coupled receptor for bradykinin, encoded by the BDKRB2. The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.Kallidin also signals through the B2 receptor.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC344Hu01 Recombinant Bradykinin Receptor B2 (BDKRB2) In Stock
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to Bradykinin Receptor B2 (BDKRB2) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPC344Ra01 Recombinant Bradykinin Receptor B2 (BDKRB2) In Stock
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