Chemokine (C-X-C Motif) Ligand 14 (CXCL14)

Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine).Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines.

CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts.However, it is reduced or absent from most cancer cells.This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2).