C-Type Natriuretic Peptide (CNP)
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C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, has been found at its highest tissue concentrations in the anterior pituitary, where it is localised in gonadotrophs. Its specific guanylyl cyclase-containing receptor, GC-B, is also expressed on several anterior pituitary cell types, and CNP potently stimulates cGMP accumulation in rat pituitary cell cultures and pituitary cell lines. The mouse gonadotroph-derived alpha T3-1 cell line has been shown to express CNP as well as GC-B (but not GC-A) receptors, suggesting that CNP may well be an autocrine regulator of gonadotrophs. Protein kinase C activation with phorbol esters also inhibited CNP-stimulated cGMP accumulation and such inhibition was also seen in cells desensitised by pretreatment with CNP. Thus it appears that the endogenous GC-B receptors of alpha T3-1 cells are subject to both homologous and heterologous desensitisation, that the mechanisms underlying these forms of desensitisation are distinct, and that cGMP elevation alone is insufficient to desensitise GC-B receptors.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA721Hu01 Recombinant C-Type Natriuretic Peptide (CNP) In Stock
- Conjugated small molecules CPA721Hu21 OVA Conjugated C-Type Natriuretic Peptide (CNP) In Stock
- Polyclonal antibody PAA721Hu01 Polyclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Monoclonal antibody MAA721Hu22 Monoclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Polyclonal antibody PAA721Hu08 Polyclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Sandwich ELISA SEA721Hu ELISA Kit for C-Type Natriuretic Peptide (CNP) In Stock
- Competition ELISA CEA721Hu ELISA Kit for C-Type Natriuretic Peptide (CNP) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPA721Mu01 Recombinant C-Type Natriuretic Peptide (CNP) In Stock
- Recombinant protein RPA721Mu02 Recombinant C-Type Natriuretic Peptide (CNP) In Stock
- Conjugated small molecules CPA721Mu21 OVA Conjugated C-Type Natriuretic Peptide (CNP) In Stock
- Polyclonal antibody PAA721Mu01 Polyclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Polyclonal antibody PAA721Mu02 Polyclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Sandwich ELISA SEA721Mu ELISA Kit for C-Type Natriuretic Peptide (CNP) In Stock
- Competition ELISA CEA721Mu ELISA Kit for C-Type Natriuretic Peptide (CNP) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPA721Ra01 Recombinant C-Type Natriuretic Peptide (CNP) In Stock
- Conjugated small molecules CPA721Ra21 OVA Conjugated C-Type Natriuretic Peptide (CNP) In Stock
- Polyclonal antibody PAA721Ra01 Polyclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Monoclonal antibody MAA721Ra21 Monoclonal Antibody to C-Type Natriuretic Peptide (CNP) In Stock
- Sandwich ELISA SEA721Ra ELISA Kit for C-Type Natriuretic Peptide (CNP) In Stock
- Competition ELISA CEA721Ra ELISA Kit for C-Type Natriuretic Peptide (CNP) In Stock