CUB Domain Containing Protein 1 (CDCP1)

CUB domain-containing protein 1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface.

It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported. RT-PCR and Northern blot analysis revealed highest CDCP1 expression in colon and lung adenocarcinomas. Expression was lower in normal colon, lung, testis, esophagus, stomach, rectum, prostate, placenta, and peripheral blood lymphocytes, and no expression was detected in pancreas.