CUGBP Elav Like Family, Member 1 (CELF1)

The CUGBP1binding only to the RNA repeat (CUG)8 was inhibited by nonlabeled (CUG)8 but not by nonlabeled single- or double-stranded CTG repeats. Furthermore, the protein, designated CUG-binding protein (CUGBP) by the authors, exhibited no binding to an RNA oligonucleotide of triplet repeats of the same length but having a different sequence, CGG. The CUG-binding protein was localized to the cytoplasm, whereas double-stranded DNA binding proteins were localized to the nuclear extract.

The deduced protein contains 2 N-terminal RNA recognition motifs (RRMs), a long linker region, and a C-terminal RRM. BRUNOL2 and BRUNOL3 (CUGBP2) share 80% amino acid identity overall and more than 92% identity in their RRMs.