Chemokine C-X-C-Motif Receptor 3 (CXCR3)

CD183 (CXCR3) is a multi-pass type-3, 7 span 368 aa glycoprotein.  It contains an extracellular domain which contains 3 potential amino-glycosylation sites, 7 putative transmembrane-spanning domains and an intracellular carboxyl-terminal regions which has 3 intracellular loop regions.  

The intracellular carboxyl-terminal region contains 10 Thr/Ser residues that may become phosphorylated during CD183-mediated signaling.  The DRYLAIVHA-motif in the 2nd intracellular loop is the most highly conserved sequence element in chemokine receptors.  CD183 is a chemokine receptor which are G-proteins coupled receptors.  CD183 shares a 30% identity with CD181 (CXCR1) and CD182 (CXCR2).