Calcineurin Binding Protein 1 (CABIN1)

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. Calcineurin-binding protein cabin-1 binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction.

The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined.May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals.