Calcium Channel, Voltage Dependent, Gamma Subunit 5 (CACNg5)

Voltage-dependent calcium channels couple membrane depolarization in a number of cellular processes. These activities are regulated by distinct channels composed of alpha-1, beta, alpha-2/delta, and gamma subunits.

By targeted genomic screening for sequences similar to CACNG1 and mouse Cacng2, Burgess et al. (1999) cloned CACNG3, CACNG4, and CACNG5. The deduced 296-amino acid CACNG5 transmembrane protein is 32% identical to CACNG2. By RT-PCR analysis of 24 adult and fetal tissues, Burgess et al. (2001) detected highest expression of CACNG5 in adult and fetal brain, spinal cord, and testis.By genomic sequence analysis, Burgess et al. (1999) determined that the CACNG5 gene contains 4 exons.