Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S)
CACNL1A3; CCHL1A3; Cav1.1; HOKPP; MHS5; hypoPP; DHPR; Dihydropyridine Receptor; Voltage-gated calcium channel subunit alpha Cav1.1
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CACNa1S encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. Cav1.1 is a voltage-dependent calcium channel found in the transverse tubule of muscles. In skeletal muscle it associates with the ryanodine receptor RyR1 of the sarcoplasmic reticulum via a mechanical linkage. It senses the voltage change caused by the end-plate potential from nervous stimulation and propagated by sodium channels as action potentials to the T-tubules. When the muscle depolarises, the channel opens to allow calcium entry, as well as activating RyR1 which mediates much greater calcium entry from the sarcoplasmic reticulum.
Organism species: Homo sapiens (Human)
- Recombinant protein RPF235Hu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
- Customized Service n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPF235Mu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
- Recombinant protein RPF235Mu02 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
- Polyclonal antibody PAF235Mu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
- Polyclonal antibody PAF235Mu02 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
- Sandwich ELISA SEF235Mu ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPF235Ra01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) In Stock
- Customized Service n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) ELISA Kit Customized Service Offer