Carbohydrate Kinase Domain Containing Protein (CARKD)

CARKD is conserved throughout many species, and has predicted orthologs through eukaryotes, bacteria, and archea.This protein is part of the phosphomethylpyrimidine kinase: ribokinase / pfkB superfamily. This family is characterized by the presence of a domain shared by the family. CARKD contains a carbohydrate kinase domain.

CARKD appears to be ubiquitously expressed at high levels. Expression data in the human protein, and the mouse ortholog, indicate its expression in almost all tissues. One peculiar expression pattern of CARKD is its differential expression through the development of oligodendrocytes. It's expression is lower in oligodendrocyte progenitor cells than in mature oligodendrocytes.