Carboxylesterase 1C (CES1C)

Carboxylesterase 1C is an enzyme with carboxylic ester hydrolase activity, it mainly acts on ester bonds, it works in lipid catabolic process and response to bacterium. The enzyme is a kind of glycoprotein, it is expressed in endoplasmic reticulum of lung, kindney and liver, and it is reported to involve in the detoxification of xenobiotics and the extracellular metabolism of lung surfactant. Ces1C and Cyp7a1 are the main enzymes in cholesterol metabolism, yet the result of western blotting was not consistent with qPCR. The present study demonstrated that metformin may affect the expression of numerous hepatic genes involved in metabolic pathways, particularly the lipid and cholesterol metabolic pathways. Ces1C and Cyp7a1 may be considered novel therapeutic target genes in the liver, which are involved in the antidiabetic effects of metformin.