Carboxypeptidase A2, Pancreatic (CPA2)

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues. The full-length cDNA encodes a deduced 417-amino acid protein, which includes a short leader sequence and a 94-amino acid long activation segment.

The human CPA2 protein shares 89% similarity with the rat CPA2 protein and 64% similarity with human CPA1. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues, in contrast to the A1 form, which shows a preference for the aliphatic C-terminal residues of peptide substrates.