Caspase 8 Associated Protein 2 (CASP8AP2)
CED-4; FLASH; RIP25; FLICE-Associated Huge Protein
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CASP8AP2 is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.FLASH was required for 3-prime end processing of histone pre-mRNA. Truncation analysis showed that the N-terminal domain of FLASH interacted with an N-terminal domain of the U7 snRNP-specific subunit LSM11. Drosophila Flash also interacted directly with human and Drosophila LSM11.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Caspase 8 Associated Protein 2 (CASP8AP2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPJ487Ra01 Recombinant Caspase 8 Associated Protein 2 (CASP8AP2) In Stock
- Monoclonal antibody MAJ487Ra21 Monoclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) In Stock
- Polyclonal antibody PAJ487Ra01 Polyclonal Antibody to Caspase 8 Associated Protein 2 (CASP8AP2) In Stock
- Sandwich ELISA SEJ487Ra ELISA Kit for Caspase 8 Associated Protein 2 (CASP8AP2) In Stock