Cell Division Cycle Protein 37 Like Protein 1 (CDC37L1)

CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA) as well as several other proteins involved in HSP90-mediated protein folding.

The deduced 337-amino acid protein has a predicted molecular mass of 38.7 kD. HARC shares 31% identity with CDC37 and 88% identity with mouse Harc. Northern blot analysis detected high expression in human liver and skeletal muscle, with lower levels in kidney, heart, brain, and placenta. HARC and CDC37 binding to HSP90 were mutually exclusive. HARC did not bind Src527F (SRC) or RAF1. HARC was serine phosphorylated by Src family kinase Hck499F (HCK ) and that both phosphorylated and nonphosphorylated HARC forms associated with HSP90.