Cerebral Microvascular Smooth Muscle Cells ( CMSMC)

Cerebral microvascular smooth muscle cells (CMSMCs) are critical components of the brain's microvasculature, playing a vital role in regulating cerebral blood flow and maintaining the integrity of the blood-brain barrier. These cells are located in the walls of arteries and arterioles within the brain, where they modulate cerebrovascular dynamics in response to the brain's metabolic demands. Their dysfunction is implicated in various neurodegenerative pathologies, including stroke, vascular dementia, and Alzheimer's disease . 

CMSMCs, as part of the neurovascular unit, are essential for the homeostasis and regulation of cerebral blood flow. The neurovascular unit comprises neurons, astrocytes, endothelial cells, pericytes, and smooth muscle cells, all working together to ensure proper brain function. At the arterial level, smooth muscle cells are the primary components wrapping around the outside of cerebral blood vessels. These cells exhibit remarkable plasticity, allowing them to adapt their structure and function in response to various environmental stimuli.