Chemokine C-C-Motif Receptor 4 (CCR4)

Chemokine (C-C motif) receptor 4, is a protein belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2 (MCP-1) ;CCL4 (MIP-1) ;CCL5 (RANTES) ;CCL17 (TARC);CCL22 (Macrophage-derived chemokine)
As Th2 type lymphocytes orchestrate the cardinal features of allergic asthma, inhibiting their recruitment to the lungs could be of therapeutic benefit. Although human Th2 cells express the CCR4 chemokine receptor and increased production of CCR4 ligands has been found in asthmatic airways, studies in animals have reached contradictory conclusions on whether blocking this pathway would be beneficial.