Chemokine Like Factor Superfamily 6 (CKLFSF6)

Members of the chemokine-like factor superfamily, including CKLFSF6, share similarity with both the chemokine and the transmembrane 4 superfamilies of signaling molecules.

By screening databases for sequences that share homology with chemokine-like factor (CKLF), followed by RT-PCR of a prostate cDNA library, Han et al. (2003) cloned CKLFSF6. The deduced 183-amino acid CKLFSF6 protein has 4 transmembrane segments. It shares about 31% sequence identity with CKLFSF4 . Northern blot analysis detected a transcript of 3.88 kb expressed in leukocytes, placenta, and testis. A smaller transcript was also detected in leukocytes. Han et al. (2003) cloned mouse Cklfsf6, which shares about 88.5% sequence similarity with CKLFSF6.