Chimerin 1 (CHN1)

Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may be involved in signal transduction.

This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding.Also known as alpha-1-chimerin, n-chimerin is a brain GTPase-activating protein (GAP) for the RAS-related p21 (RAC). Hall et al. (1993) found another form of chimerin, termed alpha-2-chimerin, and showed that it is the product of an alternately spliced transcript of the human n-chimerin gene. The mRNAs corresponding to the 2 forms of chimerin were expressed differently.