Chloride Channel Accessory 1 (CLCA1)

CLCA1 encodes a member of the calcium sensitive chloride conductance protein family. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined.

The CLCA1 cDNA encodes a deduced 914-amino acid protein with a calculated molecular mass of 100.9 kD. Human CLCLA1 shares 67% amino acid identity with mouse Clca1, bovine CLCA1, and bovine Lu-ECAM-1. The predicted human CLCLA1 protein has a signal sequence, 4 transmembrane domains, a large hydrophobic region at its C terminus, and a number of potential glycosylation and phosphorylation sites.