Cholecystokinin B Receptor (CCKBR)

The Cholecystokinin B receptor is also known as CCKBR or CCK2, with CCK2 now being the IUPHAR-recommended name. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract.

This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. Cholecystokinin B receptor has been shown to interact with Cholecystokinin.