Chromodomain Helicase DNA Binding Protein 5 (CHD5)

Changes in gene expression are associated with changes in chromatin structure, which can result from modification of histones by acetylation and methylation. In addition, SWI/SNF proteins can effect chromatin structure and gene expression by causing ATP-dependent disruption of the nucleosome and by enhancing binding of transcription factors.

CHD5 belongs to a group of SWI/SNF proteins called CHD proteins, which contain a SWI/SNF-like helicase/ATPase domain, as well as a DNA-binding domain and a chromodomain that directly modifies chromatin structure. CHD5 May play a role in the development of the nervous system and the pathogenesis of neural tumors. Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland.