Chromodomain Helicase DNA Binding Protein 4 (CHD4)

Chromodomain-helicase-DNA-binding protein 4 is an enzymebelongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.Seelig et al. (1996) noted that the Mi2-alpha (CHD3) and Mi2-beta proteins react with most or all dermatomyositis patient anti-Mi2 sera. While these proteins are distinct, they have stretches of identical sequences that could result in shared epitopes. The authors stated that Mi2-alpha and Mi2-beta contain a PHD motif, which is a zinc finger-like motif with a cys4-his-cys3 pattern and which is thought to be a DNA- or RNA-binding domain.