Clathrin, Heavy Polypeptide (CLTC)

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. Clathrin molecules have a triskelion structure composed of 3 noncovalently bound heavy chains (CLTC) and 3 light chains.

CHC overexpression enhanced p53-dependent transactivation, whereas reduction of CHC expression by RNA interference attenuated p53 transcriptional activity. CHC bound to a p53-responsive promoter in vivo and stabilized the interaction between p53 and p300 (EP300) to promote p53-mediated transcription.