Cluster Of Differentiation 1b (CD1b)

CD1B Antigen B Polypeptide; T-cell surface glycoprotein CD1b

Cluster Of Differentiation 1b (CD1b)
CD1B is a group-1 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. See CD1A for background information on CD1 molecules.CD1B is located in the late endosome or lysosome. Access to the endocytic pathway is regulated by a tyrosine-based motif in the cytoplasmic tail of CD1 that differs among CD1B, CD1C, and CD1D
CD1B, but not other CD1 isoforms, binds the AP3 adaptor protein complex. In AP3-deficient cells from patients with Hermansky-Pudlak syndrome-2 (HPS2), which is caused by mutations in the AP3B1 gene, CD1B fails to gain access to lysosomes efficiently and is mislocalized to the plasma membrane and early endosomes. The failure in CD1B trafficking results in a profound failure to present microbial lipid antigens efficiently.

Organism species: Homo sapiens (Human)