Cluster Of Differentiation 247 (CD247)

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Comparison of the human and murine genes showed a high degree of conservation, including conservation in the nucleotide sequence of the 5-prime and 3-prime untranslated regions. No significant sequence and structural homology was found, however, with the previously characterized invariant delta, gamma, and epsilon chains of the T-cell receptor.