Immunoglobulin Superfamily, Member 12 (IGSF12)

CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).By screening a cDNA library with a probe to CMRF35, Green et al. (1998) identified a cDNA encoding CMRF35H, which they called CMRF35H9.

The deduced 301-amino acid type I transmembrane protein contains a leader sequence; an extracellular region with a single V-like Ig domain and 2 conserved N-linked glycosylation sites; a membrane proximal region with potential O-linked glycosylation sites and a proline-rich, relatively rigid hinge region; a transmembrane domain; and a long cytoplasmic domain containing 4 potential immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and 2 dileucine motifs, which are associated with endocytosis.