Protease Activated Receptor 1 (PAR1)

Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, but also on endothelial cells, myocytes and neurons.There are 4 known protease-activated receptors or PARs, numbered from one to four.

Coagulation factor II (thrombin) receptor 1 is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. PAR1 is a G-protein coupled receptor.Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease.