Complement Component 8b (C8b)
Complement component 8 subunit beta
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Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.Patients with deficiency of C8 suffer from recurrent neisserial infections, predominantly with meningococcus infection of rare serotypes. Most such patients are discovered among those having their first episode of meningitis at ages older than 10 years. C8 deficiency of the alpha and gamma subunits was found in 4 black families and no Caucasian families by Ross and Densen (1984), whereas C8B deficiency was reported in 12 Caucasian kindreds and no black kindreds. Wulffraat et al. (1994) described a family in which a 13-year-old boy was found to be homozygous for C8B deficiency and to have juvenile chronic arthritis of 6 months' duration.Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB306Hu01 Recombinant Complement Component 8b (C8b) In Stock
- Active protein APB306Hu01 Active Complement Component 8b (C8b) In Stock
- Polyclonal antibody PAB306Hu01 Polyclonal Antibody to Complement Component 8b (C8b) In Stock
- Monoclonal antibody MAB306Hu21 Monoclonal Antibody to Complement Component 8b (C8b) In Stock
- Sandwich ELISA SEB306Hu ELISA Kit for Complement Component 8b (C8b) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPB306Mu01 Recombinant Complement Component 8b (C8b) In Stock
- Polyclonal antibody PAB306Mu01 Polyclonal Antibody to Complement Component 8b (C8b) In Stock
- Customized Service n/a CLIA Kit for Complement Component 8b (C8b) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Complement Component 8b (C8b) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPB306Ra01 Recombinant Complement Component 8b (C8b) In Stock
- Polyclonal antibody PAB306Ra01 Polyclonal Antibody to Complement Component 8b (C8b) In Stock
- Customized Service n/a CLIA Kit for Complement Component 8b (C8b) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Complement Component 8b (C8b) ELISA Kit Customized Service Offer