Complement Receptor 1, Erythrocyte (CR1)

CD35; C3BR; KN; C3b/C4b Receptor,Including Knops Blood Group System; Immune Adherence Receptor

Complement Receptor 1, Erythrocyte (CR1)

Erythrocyte complement receptor 1 is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein.

The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.

Organism species: Homo sapiens (Human)