Contactin 3 (CNTN3)

Pang, a mouse gene encoding a neuronal adhesion molecule, was isolated as a plasmacytoma-specific transcript using an RT-PCR-based strategy in an attempt to isolate Myc-like genes in murine plasmacytomas . Pang is a member of the immunoglobulin/fibronectin superfamily of adhesion molecules; its closest relatives, TAG1 and contactin-1, promote axon growth and migration.

The normal site of Pang expression is the brain, where it is detected as 4.0- and 6.1-kb RNAs on Northern blots; Pang is not detected in other normal tissues. Abnormally sized Pang transcripts were uniquely found in murine plasmacytomas, where it is ectopically activated by intracisternal A-type particle long terminal repeats.