Cysteine And Glycine Rich Protein 3 (CSRP3)

CSRP3 encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans.

The rat cDNA was designated muscle LIM protein (Mlp) because it contains a cysteine-rich domain originally described in the 3 proteins Lin-11, Isl-1, and Mec-3. Mlp is enriched in striated muscle and its expression coincides with myogenic differentiation.