Cytospin B (CYTSB)

Database analysis showed that the SPECC1 gene is almost identical to the human sperm antigen, HCMOGT1. There are 2 possible 5-prime ends and 2 possible 3-prime ends. The major coding sequence shared by all isolated transcripts encodes an ATPase domain similar to that of SMC family members and a coiled-coil domain commonly seen in motor or structure proteins.

The larger transcript was also expressed in spleen, but all other normal tissues examined showed little or no SPECC1 expression. Variable expression was detected in some human cancer cell lines, including HeLa cells. Immunohistochemical analysis of HeLa cells detected SPECC1 in the nucleus.